From: Identification of hot-spot residues in protein-protein interactions by computational docking
PPV | S | |
---|---|---|
Initial dataset (21 cases)a | ||
NIP ≥ 0.2 | 68% | 43% |
NIP ≥ 0.4 | 78% | 24% |
FOLDEF | 73% | 46% |
ROBETTAb | 71% | 69% |
Li's dataset (15 cases)c | ||
NIP ≥ 0.2 | 75% | 42% |
NIP ≥ 0.4 | 91% | 26% |
FOLDEFd | 70% | 45% |
ROBETTAd | 64% | 60% |
Additional dataset (all 22 cases)e | ||
NIP ≥ 0.2 | 59% | 34% |
NIP ≥ 0.4 | 78% | 15% |
Additional dataset (X-ray subunits)e | ||
NIP ≥ 0.2 | 73% | 44% |
NIP ≥ 0.4 | 80% | 19% |
Additional dataset (NMR subunits)e | ||
NIP ≥ 0.2 | 0% | 0% |
NIP ≥ 0.4 | 0% | 0% |
Additional dataset (modeled subunits)e | ||
NIP ≥ 0.2 | 59% | 33% |
NIP ≥ 0.4 | 75% | 15% |