Figure 6

Ligand-binding Positions of Tyrosine Aminotransferase of Trypanosoma Cruzi. One chain of the crystal structure of tyrosine aminotransferase from Trypanosoma Cruzi (PDB code 1BW0). Results of a conservation-based measure (Williamson, in blue) are shown compared to the phylogeny-based SMERFS (in red). Positions predicted by both techniques are shown in green, the PLP cofactor in orange. Protein regions in stick representation and labelled are those important for cofactor binding, as described in the text.