Figure 1

Flow chart for identifying SNPs in putative promoter regions. Cylinders represent databases. Rectangles are computational applications. (a) Putative promoter regions are identified in the human genome sequence. (b) Transcription binding sites are predicted in the putative promoter regions by using TransFac database. (c) SNPs are mapped. (d) Evolution conservation scores are calculated within transcription factor binding sites. (e) The disease association and functional annotation of target genes carried out by using an in-house functional annotation database.