Table 3 Comparison of the performance between the profile-based methods and existing allergenicity prediction systems
From: The value of position-specific scoring matrices for assessment of protein allegenicity
Method | ACC (%) | SP (%) | SE (%) | PPV (%) | NPV (%) | MCC (%) |
|---|---|---|---|---|---|---|
General profile model | 95.02 | 96.92 | 82.45 | 81.34 | 97.34 | 0.79 |
Group-specific profile model | 94.88 | 96.52 | 84.04 | 79.49 | 97.56 | 0.79 |
FAO/WHO [5] | 31.58 | 23.31 | 86.36 | 14.55 | 91.83 | 0.08 |
SVM (global description) [8] | 93.01 | 95.40 | 77.22 | 59.02 | 96.52 | 0.71 |
SVM (aa composition) [14] | 61.77 | 57.61 | 89.33 | 24.14 | 97.28 | 0.32 |
SVM (dipeptide composition) [14] | 61.73 | 57.55 | 89.40 | 24.12 | 92.29 | 0.32 |
MEME/MAST motifs [12] | 86.84 | 99.75 | 1.26 | 31.59 | 87.00 | 0.04 |
ARP [15] | 61.55 | 57.45 | 88.74 | 18.92 | 97.12 | 0.31 |