Drug interaction prediction using ontology-driven hypothetical assertion framework for pathway generation followed by numerical simulation

Table 2 The major properties of molecular event objects in OWL-DL.

Properties	Domain (class)	Range (class)
oboRel:relationship	Process, Continuant	Process, Continuant
-oboRel:located in	independent_entities	Independent_entities, fma:Anatomical_cavity
-oboRel:has_participant	Process	Independent_entities
-- hasResultantParticipant	Process	Independent_entities
-- hasTriggerParticipant	Process	Independent_entities
-- hasSituatedParticipant	Process	Independent_entities
hasSubProcesses	Process	Process
occurred_in	Process	Independent_entities, fma:Anatomical_cavity

The relations among molecular events, attributes (continuants) and drug interactions shown in Figure 2 were implemented as OWL properties. We defined five properties for implementing molecular event objects in OWL-DL in addition to the properties of OBO Relation ontology. Three properties for resultant, trigger, and situated participants were defined as sub properties of oboRel:has_participant, inheriting the definition of the super property. Note that classes for Domain and Range of properties are denoted by the controlled vocabulary defined in Figure 3.

ISSN: 1471-2105