Enzyme | Substrate | Product | K m [μ M] | V max [pmol/min/mg protein] | α[mg protein/g tissue] | V max ·α/K m [mL/min/g tissue] |
---|---|---|---|---|---|---|
Carboxylesterase | Irinotecan | SN-38 | 2.30 | 2.11 | 128 | 0.117 |
Carboxylesterase | NPC | SN-38 | 2.30 | 2.11 | 128 | 0.117 |
CYP3A4 | Irinotecan | APC | 18.4 | 26.0 | 73.3 | 0.104 |
CYP3A4 | Irinotecan | NPC | 48.2 | 74.1 | 11.7 | 0.0180 |
UGT1A1 | SN-38 | SN-38G | 3.80 | 50.8 | 750 | 10.0 |
CYP3A4 | KCZ | MOK | 0.00810 | 12.5 | 44.3 | 68.4 |