From: Exhaustive prediction of disease susceptibility to coding base changes in the human genome
 | HGMD | dbSNP |  |  |  |  | ||
---|---|---|---|---|---|---|---|---|
 | TP | FN | TN | FP | Sensitivity | Specificity | Accuracy | F-measure |
 | Testing set created using random mutations not used for training | |||||||
SVM Complete ; Max | 16527 | 3567 | 64378 | 12454 | 82.2 | 83.8 | 83.5 | 67.4 |
SVM Conservation Only ; Max | 14467 | 5627 | 49178 | 27659 | 72.0 | 64.0 | 65.7 | 46.5 |
 | Testing set created to allow comparison with SIFT | |||||||
SIFT | 159 | 245 | 13995 | 5281 | 39.4 | 72.6 | 71.9 | 5.4 |
SVM Complete | 287 | 117 | 12049 | 7227 | 71.0 | 62.5 | 62.7 | 7.2 |
SVM Conservation Only | 230 | 174 | 10216 | 9060 | 56.9 | 53.0 | 53.1 | 4.7 |