Figure 6
From: DomSign: a top-down annotation pipeline to enlarge enzyme space in the protein universe
Expansion of enzyme space in HMP non-redundant proteins by DomSign (specificity threshold = 80%). The circles illustrate the distribution of four kinds of proteins in the HMP non-redundant dataset. Red: enzymes with EC numbers annotated exclusively by HMP; blue: novel enzymes exclusively predicted by DomSign; green: enzymes identified by both HMP and DomSign; purple: all remaining proteins. The column on the right represents the ratio of EC hierarchy levels for predicted novel enzymes by DomSign, similar to the description in Figure 5.