Fig. 4From: DECIPHER: harnessing local sequence context to improve protein multiple sequence alignmentContribution of local sequence context to the cost of opening a gap in the alignment. Hydrophobic residues greatly decrease the likelihood of a gap, whereas hydrophilic and “structure-breaking” residues increase the likelihood of a gap. In the gap model, positions located within four residues were used to modulate the cost of opening a gap at position zeroBack to article page