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Table 4 P-values of the four methods for detecting the genes in the PI3K-AKT signaling pathway and Notch signaling pathway

From: A powerful score-based statistical test for group difference in weighted biological networks

Gene

NetDifM

NetDifMpm

VEWDM

Yates’D

PI3K-AKT signaling pathway

  KRAS

0.19521

0.190

0.551

0.499

  PIK3CA

0.49654

0.531

0.531

0.891

  IRS1

0.06622

0.066

0.031

0.207

  PDPK1

0.05108

0.042

0.032

0.143

  AKT1

0.13639

0.146

0.065

0.712

  MDM2

0.03568

0.035

0.011

0.484

  TP53

0.08385

0.083

0.136

0.102

Notch signaling pathway

  DLL3

0.05909

0.062

0.081

0.559

  DTX2

0.42435

0.412

0.202

0.122

  CREBBP

0.20470

0.220

0.191

0.650

  PTCRA

0.51705

0.507

0.421

0.192

  JAG1

0.03144

0.027

0.036

0.142

  DVL2

0.00124

<0.001

<0.001

0.639

  SNW1

0.71303

0.706

0.309

0.124

  HES1

0.01032

0.002

0.035

0.995

  RBPJ

0.00001

<0.001

<0.001

0.646

  NOTCH2

0.00014

<0.001

<0.001

0.095

  PSENEN

0.42405

0.435

0.102

0.032

  ADAM17

0.00701

0.009

0.009

0.326

  NUMB

0.10758

0.098

0.065

0.100

  NCOR2

0.00021

<0.001

<0.001

0.344