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Table 9 List of molecular function GO terms significantly enriched and uniquely appearing in each topic for embryonic mouse cell differentiation

From: CellTree: an R/bioconductor package to infer the hierarchical structure of cell populations from single-cell RNA-seq data

GO.ID

Term

p-Value

Topic 2

GO:0001054

RNA polymerase I activity

2.5e-07

GO:0043022

ribosome binding

4.8e-06

GO:0030515

snoRNA binding

5.0e-06

GO:0005524

ATP binding

6.1e-06

Topic 3

GO:0003713

transcription coactivator activity

7.6e-07

GO:0003730

mRNA 3’-UTR binding

4.6e-06

GO:0004843

ubiquitin-specific protease activity

7.7e-06

Topic 4

GO:0020037

heme binding

2.2e-19

O:0008395

steroid hydroxylase activity

5.9e-18

O:0019825

oxygen binding

6.5e-14

O:0005506

iron ion binding

9.2e-13

O:0004364

glutathione transferase activity

1.5e-12

O:0008392

arachidonic acid epoxygenase activity

1.9e-12

O:0005102

receptor binding

4.2e-11

GO:0004867

serine-type endopeptidase inhibitor activity

1.1e-10

GO:0009055

electron carrier activity

1.3e-10

GO:0070330

aromatase activity

2.6e-10

GO:0042803

protein homodimerization activity

7.4e-10

GO:0008201

heparin binding

1.5e-09

GO:0002020

protease binding

2.5e-08

GO:0051087

chaperone binding

6.0e-07

GO:0003988

acetyl-CoA C-acyltransferase activity

8.4e-07

GO:0016836

hydro-lyase activity

1.0e-06

GO:0004602

glutathione peroxidase activity

1.0e-06

GO:0004601

peroxidase activity

1.3e-06

GO:0030170

pyridoxal phosphate binding

1.6e-06

GO:0004029

aldehyde dehydrogenase (NAD) activity

2.4e-06

GO:0001848

complement binding

3.1e-06

GO:0016616

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

3.2e-06

GO:0050660

flavin adenine dinucleotide binding

3.8e-06

GO:0005507

copper ion binding

4.1e-06

GO:0016709

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

5.3e-06

GO:0032403

protein complex binding

5.7e-06

GO:0051537

2 iron, 2 sulfur cluster binding

7.8e-06