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Table 1 Summary of existing removal tools listed together with some of their relevant features

From: Removing duplicate reads using graphics processing units

Tool

Strategy

Libraries

Platform

Type

Picard MarkDuplicates

alignment-based

single- and paired-end

Illumina and 454

nearly-identical

samtools rmdup

alignment-based

single- and paired-end

Illumina and 454

nearly-identical

SEAL

alignment-based

paired-end

Illumina

nearly-identical

FastX-Toolkit Collapser

alignment-free

single-end

Illumina and 454

identical

FastUniq

alignment-free

paired-end

Illumina and 454

identical

Fulcrum

alignment-free

single- and paired-end

Illumina and 454

nearly-identical

CD-HIT-454

alignment-free

single- and paired-end

454

nearly-identical

CD-HIT-DUP

alignment-free

single- and paired-end

Illumina

nearly-identical

  1. The second column indicates the implemented strategy. The third column reports whether the corresponding tool support single- and/or paired-end read libraries. The fourth column reports the sequencing platforms supported. The fifth column reports whether the corresponding tool is able to remove only identical or nearly-identical duplicates