Table 1 Glossary of solution methods
From: solveME: fast and reliable solution of nonlinear ME models
Method | Description |
|---|---|
bisectME | Maximizes growth rate μ via binary or golden section search [15]. Uses Quad MINOS to solve LP subproblems in quad precision [10]. Every LP after the first is warm-started using the previous solution. |
solveME | Combined solution procedure for the nonlinear growth-rate maximization problem Eq. (1). Uses bisectME to find a feasible estimate μ 0, which is used to compute μ (and all fluxes) to high precision using the Quad MINOS NLP solver. |
varyME | Flux variability analysis [16] in quad precision with solver warm-starts [17]. |