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Table 4 Analysis of the Rfam 12.0 database

From: RNAdualPF: software to compute the dual partition function with sample applications in molecular evolution theory

MEASURE

GC 5 %

Exact GC

No GC

WT

BP DIST TARGET

0.1 ±0.05

0.1 ±0.05

0.16 ±0.07

0 ±0

ENERGY MFE

–0.43 ±0.13

–0.43 ±0.13

–0.64 ±0.16

–0.28 ±0.13

ENERGY TARGET

–0.36 ±0.14

–0.36 ±0.14

–0.54 ±0.19

–0.28 ±0.13

ENSEMBLE DEFECT

0.18 ±0.07

0.18 ±0.07

0.25 ±0.11

0.16 ±0.12

EXP BP DIST

0.11 ±0.05

0.11 ±0.05

0.17 ±0.07

0.1 ±0.08

PROP NAT CONTACT

0.87 ±0.09

0.87 ±0.09

0.78 ±0.14

0.81 ±0.17

POS ENTROPY

0.22 ±0.09

0.21 ±0.09

0.25 ±0.1

0.4 ±0.25

GC CONTENT

46.27 ±10.91

46.27 ±10.91

75.12 ±5.89

46.27 ±10.91

LN DUAL PROB

–110.35 ±54.12

–110.34 ±54.12

–73.5 ±33.32

–136.7 ±65.62

LN PROB

–13.94 ±7.74

–13.9 ±7.71

–18.11 ±10.59

–2.83 ±1.71

MH STR DIV

0.12 ±0.05

0.12 ±0.05

0.13 ±0.05

0.2 ±0.12

VIENNA STR DIV

0.07 ±0.03

0.07 ±0.03

0.09 ±0.04

0.13 ±0.08

  1. For each RNA family from Rfam 12.0, we selected that sequence whose MFE structure had smallest base pair distance to the Rfam consensus structure for the family. These sequences constituted the collection WT. See Table 3 for an explanation of column headers and various measures