Fig. 2

Workflow overview of the results provided by the methodology proposed. a Expression patterns (clusters) found using SOM on the correlations obtained for each gene along the stages with the Gamma rank correlation. Highlighted in blue the 4 patterns selected (for the case of the MDS dataset) as the most representative of 9 profiles explored, which included most of the features and the largest changes: 2 increasing (p1 and p2) and 2 decreasing (p3 and p4). b Standardized and sorted expression of the genes included in each pattern. Blue: samples in control or initial stages; red: samples in late or acute stage; grey: intermediate stages. c Boxplots of the expression signals of four example genes that follow each one of the 4 patterns found. These genes also correspond to the MDS dataset and the plots include 6 stages of the disease