Table 1 Average tool analysis time for high coverage data (30x < coverage < 100x)

Segmentum

- 10 h 34 min for extracting RD from normal or tumor BAM file

- 4 h 25 min for calculating BAF values

- 1 min 45 s

Patchwork

- 29 h 37 min for creating pileups from normal or tumor BAM file

- 3 h 56 min

Control-FREEC

- 33 h 28 min for creating pileups from normal or tumor BAM file

- 7 h 11 min

CLImAT

- 2 h 12 min for extracting RD

- 29 min