Fig. 3

The FEATURE program. FEATURE captures the physicochemical information around a point of interest in protein structure by segmenting the local environment into six concentric shells, each of 1.25 Å in thickness. Within each shell, FEATURE evaluates 80 physicochemical properties including atom type, residue class, hydrophobicity, and secondary structure. This enables conversion of a local structural environment into a numeric vector of length 480