Table 4 Gene Ontology enrichment analysis for genes related with 65 common SVASEs using PANTHER (filtered redundant records)
From: ISVASE: identification of sequence variant associated with splicing event using RNA-seq data
GO function | Total gene | SVASE gene | Expected | Fold Enrichment | P value (<0.05) |
|---|---|---|---|---|---|
GO biological process complete | |||||
 antigen processing and presentation of endogenous peptide antigen via MHC class I | 15 | 3 | 0.02 | >100 | 0.00541 |
 antigen processing and presentation of peptide antigen via MHC class I | 108 | 6 | 0.12 | 50.28 | 1.51E-05 |
 antigen processing and presentation of endogenous antigen | 19 | 3 | 0.02 | >100 | 0.011 |
 antigen processing and presentation of exogenous antigen | 181 | 6 | 0.2 | 30 | 0.000317 |
 response to type I interferon | 74 | 6 | 0.08 | 73.37 | 1.6E-06 |
 response to interferon-gamma | 151 | 6 | 0.17 | 35.96 | 0.000109 |
GO molecular function complete | |||||
 antigen binding | 107 | 6 | 0.12 | 50.75 | 4.69E-06 |
GO cellular component complete | |||||
 MHC protein complex | 30 | 6 | 0.03 | >100 | 1.14E-09 |
 membrane-bounded vesicle | 1169 | 9 | 1.29 | 6.97 | 0.00285 |
 vesicle membrane | 508 | 7 | 0.56 | 12.47 | 0.00116 |