Fig. 1
From: High-throughput binding affinity calculations at extreme scales
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12859-018-2506-6/MediaObjects/12859_2018_2506_Fig1_HTML.png)
EGFR Structure. Cartoon representation of the EGFR kinase bound to the inhibitor AEE788 shown in chemical representation (based on PDB:2J6M). Two residues implicated in modulating drug efficacy are highlights; in pink T790 and in orange L858. Mutations to either of these residues significantly alter the sensitivity to TKIs