Table 3 Results from BioBERT_directionalDDI applied to all human prescription drug labels from the NIH
Drug | Total sentences | PK DDI sentences | Object sentences (Unique sentences) |
|---|---|---|---|
Vandetanib Example Sentence | 923 | 132 | 16 (4) |
The coadministration of rifampicin with CAPRELSA decreased the geometric mean AUC0-504h of vandetanib by 40% (90% confidence interval (CI) 56%, 63%) compared to vandetanib alone | |||
Sotalol Example Sentence | 16,658 | 121 | 42 (9) |
Telithromycin has been shown to decrease the Cmax and AUC of sotalol by 34% and 20%, respectively, due to decreased absorption | |||
Quinidine Example Sentence | 31,266 | 7682 | 1583 (118) |
Diltiazem significantly increases the AUC of quinidine by 51%, T1/2 by 36%, and decreases its CL by 33% | |||
Ibutilide | 688 | 0 | 0 (0) |
Dofetilide Example Sentence | 8346 | 645 | 601 (60) |
Cimetidine at 400 mg BID (the usual prescription dose) co-administered with TIKOSYN (500 mcg BID) for 7 days has been shown to increase dofetilide plasma levels by 58% | |||
Disopyramide Example Sentence | 6087 | 101 | 49 (12) |
In vitro metabolic studies indicated that disopyramide is metabolized by cytochrome P450 3A4 and that inhibitors of this enzyme may result in elevation of plasma levels of disopyramide | |||
Bepridil | 149 | 0 | 0 (0) |
Azimilide | 0 | 0 | 0 (0) |
Terfenadine Example Sentence | 6135 | 1098 | 629 (29) |
In a drug interaction study in 16 healthy volunteers, co-administration of multiple doses of terfenadine (60 mg every 12 h) and ZYFLO (600 mg every 6 h) for 7 days resulted in a decrease in clearance of terfenadine by 22% leading to a statistically significant increase in mean AUC and Cmax of terfenadine of approximately 35% | |||
Risperidone Example Sentence | 68,070 | 3783 | 2250 (188) |
Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6-mediated metabolism of risperidone (administered as a single 1 mg oral dose) to its active metabolite, 9-hydroxyrisperidone, resulting in an approximate 32% increase in risperidone AUC | |||
Pimozide Example Sentence | 13,493 | 2647 | 1818 (136) |
In a controlled study of a single dose (2 mg) of pimozide, 200 mg sertraline (q.d.) coadministration to steady state was associated with a mean increase in pimozide AUC and Cmax of about 40%, but was not associated with any changes in EKG | |||
Ondansetron Example Sentence | 77,681 | 2511 | 1234 (24) |
In a pharmacokinetic study of 10 healthy subjects receiving a single-dose intravenous dose of ondansetron 8 mg after 600 mg rifampin once daily for five days, the AUC and the t1/2 of ondansetron were reduced by 48% and 46%, respectively | |||
Droperidol | 1939 | 16 | 0 (0) |
Domperidone | 0 | 0 | 0 (0) |
Clozapine Example Sentence | 16,343 | 2774 | 1773 (118) |
Following concomitant administration of 250 mg CIPRO with 304 mg clozapine for 7 days, serum concentrations of clozapine and N-desmethylclozapine were increased by 29% and 31%, respectively | |||
Clarithromycin Example Sentence | 90,366 | 10,775 | 2464 (176) |
Concomitant administration of fluconazole 200 mg daily and clarithromycin 500 mg twice daily to 21 healthy volunteers led to increases in the mean steady-state clarithromycin Cmin and AUC of 33% and 18%, respectively | |||
Cisapride Example Sentence | 6433 | 1167 | 1001 (51) |
Following a single dose of fluconazole, there was a 101% increase in the cisapride AUC and a 91% increase in the cisapride Cmax | |||
Chlorpromazine | 12,207 | 1103 | 101 (0) |
Astemizole Example Sentence | 2431 | 250 | 244 (15) |
Concomitant administration of fluconazole with astemizole may decrease the clearance of astemizole | |||
Verapamil Example Sentence | 43,977 | 7691 | 1504 (73) |
The AUC and Cmax for both verapamil and norverapamil are increased when 240 mg of controlled release verapamil is administered concomitantly with 4 mg trandolapril | |||
Tamoxifen Example Sentence | 27,560 | 961 | 401 (41) |
Data from a clinical trial in patients with breast cancer indicated that tamoxifen Cmax and AUC increased approximately twofold following coadministration of 600 mg ribociclib | |||
Ranolazine Example Sentence | 11,979 | 1932 | 620 (100) |
Plasma levels of ranolazine with RANEXA 1000 mg twice daily are increased by 50 to 130% by diltiazem 180 to 360 mg, respectively | |||
Nitrendipine | 190 | 0 | 0 (0) |
Nifedipine Example Sentence | 40,859 | 6850 | 3714 (177) |
The mean values of Cmax and AUC of nifedipine are increased by 64% and 79%, respectively, by co-administration of propranolol | |||
Mexiletine Example Sentence | 5359 | 725 | 252 (20) |
In a formal, single-dose interaction study (n = 6 males) the clearance of mexiletine was decreased by 38% following the coadministration of fluvoxamine, an inhibitor of CYP1A2 | |||
Metoprolol Example Sentence | 67,595 | 3986 | 2790 (152) |
Administration of 20 mg/day Lexapro for 21 days in healthy volunteers resulted in a 50% increase in Cmax and 82% increase in AUC of the beta-adrenergic blocker metoprolol (given in a single dose of 100 mg) | |||
Loratadine Example Sentence | 5875 | 436 | 194 (14) |
Loratadine, a non-sedating antihistaminic, is metabolized primarily by CYP3A and its metabolism can be inhibited by amiodarone | |||
Diltiazem Example Sentence | 45,605 | 10,797 | 1830 (96) |
A study in six healthy volunteers has shown a significant increase in peak diltiazem plasma levels (58%) and area-under-the-curve (53%) after a 1-week course of cimetidine at 1200 mg per day and a single dose of diltiazem 60 mg | |||