Fig. 1
From: Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction
Comparison of prediction performance in simulation studies with non-overlapping annotation groups (Settings 1–5), measured by AUC (a) and \({R}^{2}\) (b). A total of \(M=125,000\) SNPs were sampled from the UK Biobank data with 1 KG as LD reference panel. Genetic effects were generated using a mixture of point-Normal models with total heritability fixed at 0.7. GWAS results from \({N}_{sumstat}=50,000\) simulated individuals were used as summary statistics. Prediction accuracy was evaluated in a test sample of \({N}_{test}=24,000\) simulated individuals with tenfold cross-validation