Table 3 Hub transcription factor proteins involved in combination of four disorder catagory

Cardiovascular

5

ATF2, CREB3, PRDM16, SP1, TCF7L2

Hematologic

1

MYB

BPTF, CDC5L, CEBPA, CENPB, CHAMP1, EPAS1,

Neuropsychiatric

18

ESR2, FOS, LHX2, LIN28B, PAX6, PPARD,

PPARG, RBPJ, SKI, SOX5, SOX6, THAP1

ARID3A, BCL6, CENPA, DDIT3, E2F1, FOXO1,

Respiratory

18

FOXO3, JUNB, MAX, MEOX2, NPAS1, PHF1,

PITX1, RARA, RXRA, TFDP1, ZBTB16, ZNF467

Cardiovascular + Respiratory

2

ESR1, RELA

Cardiovascular + Neuropsychiatric

1

CREB5

Hematologic

BACH1, ELK3, ERG, ETS1, ETV3, GATAD2A,

+

16

GTF2B, GTF2I, HSF1, NCOA2, NFATC2,

Neuropsychiatric

RUNX1, SNAI1, THRA, ZBTB38, ZNF326

Neuropsychiatric + Respiratory

2

LTF, NR3C1

Hematologic + Respiratory

1

SMAD4

Hematologic +

Respiratory +

5

HIF1A, MYC, STAT3, STAT5A, ZNF281

Neuropsychiatric

Hematologic +

Cardiovascular +

1

CREB1

Neuropsychiatric

Hematologic + Respiratory +

Cardiovascular +

1

ATF4

Neuropsychiatric +