Table 5 Comparisons of different methods in identifying SARS-CoV-2-associated hub proteins
Methods used | Number of identified hub prteins | |
|---|---|---|
Level-1 | Level-2 | |
Machine learning [5] | 1326 | Not applicable |
Unsupervised machine learning [7] | 1300 | Not applicable |
Receiver operating characteristic (ROC) curve analysis [8] | 994 | Not applicable |
Network topological ananlysis [9] | 15 | Not applicable |
Random walk with restart (RWR) [12] | 476 | Not applicable |
Statistical R-packages (DESeq2 and edgeR) [31] | 109 | Not applicable |
2-Level-PPI-graph coloring (this research work) | 1082 | 1922 |