Table 2 Functional annotation results for identified driver genes by GSW-FI
Dataset | Terms | Genes | FDR |
|---|---|---|---|
| Â | hsa05230:Central carbon metabolism in cancer | NRAS, FLT3, IDH1, IDH2, TP53 | 3.1329E-05 |
| Â | hsa05221:Acute myeloid leukemia | CEBPA, NRAS, FLT3, RUNX1 | 0.0014 |
LAML | hsa05202:Transcriptional misregulation in cancer | CEBPA, FLT3, TP53, RUNX1 | 0.0214 |
| Â | hsa05200:Pathways in cancer | CEBPA, NRAS, FLT3, TP53, RUNX1 | 0.0234 |
| Â | hsa05220:Chronic myeloid leukemia | NRAS, TP53, RUNX1 | 0.0460 |
| Â | hsa05213:Endometrial cancer | PIK3CA, CDH1, TP53 | 0.0271 |
BRCA | hsa05218:Melanoma | PIK3CA, CDH1, TP53 | 0.0271 |
| Â | hsa04722:Neurotrophin signaling pathway | MAP3K1, PIK3CA, TP53 | 0.0493 |
| Â | hsa05225:Hepatocellular carcinoma | KEAP1, KRAS, TP53, EGFR | 0.0385 |
LUAD | hsa05223:Non-small cell lung cancer | KRAS, TP53, EGFR | 0.0385 |
| Â | hsa04151:PI3K-Akt signaling pathway | STK11, KRAS, TP53, EGFR | 0.0435 |