Table 3 Overall performance of 11 methods
Methods | sd of driver gene number | CGC overlap (%) | Mut-driver overlap (%) | HiConf overlap (%) | Method consensus (%) | CGC rank | Mut-driver rank | HiConf rank | Method consensus rank | Average rank |
|---|---|---|---|---|---|---|---|---|---|---|
Dendrix | 38.78 | 29.22 | 25.04 | 21.49 | 39.83 | 8 | 8 | 7 | 7 | 7.50 |
MutSigCV | 106.26 | 37.05 | 31.73 | 26.48 | 66.72 | 5 | 4 | 4 | 3 | 4.00 |
MEMo | 3.02 | 17.07 | 16.07 | 15.61 | 17.71 | 9 | 15 | 9 | 10 | 10.75 |
DriverNet | 44.02 | 39.41 | 33.51 | 32.37 | 36.76 | 3 | 3 | 3 | 8 | 4.25 |
e-Driver | 42.73 | 36.07 | 29.57 | 25.00 | 61.80 | 6 | 5 | 5 | 4 | 5.00 |
iPAC | 3662.54 | 11.35 | 5.31 | 3.55 | 7.2 | 11 | 11 | 11 | 11 | 11.00 |
MSEA | 355.44 | 13.35 | 7.83 | 5.82 | 14.88 | 10 | 10 | 10 | 9 | 9.75 |
DriverML | 251.56 | 48.34 | 41.48 | 34.00 | 73.99 | 2 | 2 | 2 | 1 | 1.75 |
OncodriveFML | 69.71 | 33.93 | 26.18 | 19.17 | 53.55 | 7 | 7 | 8 | 5 | 6.75 |
rDriver | 9.00 | 38.18 | 27.55 | 21.80 | 46.40 | 4 | 6 | 6 | 6 | 5.50 |
GSW-FI (\(\lambda =0\)) | 9.36 | 63.26 | 45.44 | 36.14 | – | – | – | – | – | – |
GSW-FI (\(\lambda =0.5\)) | 12.24 | 65.13 | 49.01 | 41.10 | 67.07 | 1 | 1 | 1 | 2 | 1.25 |
GSW-FI (\(\lambda =1\)) | 18.25 | 53.86 | 41.41 | 34.50 | – | – | – | – | – | – |