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Table 1 Number of DMRs and DMPs identified by different approaches

From: Gbdmr: identifying differentially methylated CpG regions in the human genome via generalized beta regressions

 

dmrff

gbdmr \(^{1}\)

EWAS

Analysis index

DMPs

DMRs

DMPs

DMRs

DMPs

1. IOW male vs. female\(^{2}\)

2085

900 (2418)

1884

1114 (3727)

3435

2. IOW male vs. female\(^{3}\)

468

148 (391)

423

649 (2352)

697

3. IOW male vs. female\(^{4}\)

1050

418 (1163)

1092

457 (1494)

1664

4. IOW male vs. female\(^{5}\)

4226

1986 (5314)

4300

1814 (5798)

7800

5. IOW gestational age\(^{5}\)

908

333 (907)

996

352 (1120)

1360

6. IOW birth weight\(^{5}\)

210

78 (220)

219

138 (547)

303

7. GSE59065 male vs. female\(^{6}\)

946

345 (1008)

1010

448 (2224)

1304

8. GSE59065 young vs. old\(^{6}\)

20453

12376 (37651)

22814

9252 (27757)

42126

9. GSE87571 male vs. female\(^{7}\)

3381

1861 (5394)

3575

1613 (5611)

6710

10. GSE87571 age\(^{7}\)

72070

28586 (87185)

101188

11741 (31409)

133507

  1. Using data in the IOW cohort and GSE datasets. DMPs: differential methylated CpG sites; DMRs: differential methylated regions that contain more than one CpG site. The number of DMR CpGs is included in the parentheses
  2. \(^{1}\) The adjacent correlation threshold used for gbdmr is 0.5. \(^{2}\) IOW dataset age 26. \(^{3}\) IOW dataset age 18. \(^{4}\) IOW dataset age 10. \(^{5}\) IOW dataset age at birth. Gestational age is used to describe how far along the pregnancy is. It is measured in weeks
  3. \(^{6}\) Age-related profiling of DNA methylation in CD8+ T cells and age is recorded as a binary variable
  4. \(^{7}\) Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan Dataset