Fig. 1
From: A protein network refinement method based on module discovery and biological information
The overall steps of the construction of the CM-PIN. First, in the block of construction of D-PIN and RD-PIN, we combined static PIN (S-PIN) and gene expression profile to construct D-PIN, and then further combined subcellular localization information to construct RD-PIN. In this paper, corresponding CM-PINs will be constructed based on these networks. Secondly, in the block of construction of CM-PIN, the Step 1 is to extract the maximum connected subgraph of a given PIN; the Step 2 is to divide the maximum connected subgraph into several modules using the Fast-unfolding algorithm; and the Step 3 is to identify critical modules using the biological (orthologous information and subcellular localization information) and topological information of proteins; the Step 4 is to refine the given PIN and construct the CM-PIN according to the identified critical modules