Table 2 Comparison of the number of essential proteins identified by 12 node ranking methods on the S-PIN, D-PIN, RD-PIN and the CM-PIN at top 100–600 on YDIP dataset

LAC

[82,144,195,

251,300,347]

[82,144,201,

263,314,366]

[77,147,202,

271,318,362]

[81,154,219,

275,330,377]

[76,147,207,

264,315,363]

[83,157,225,

288,341,391]

DC

[55,102,152,

202,256,300]

[66,121,190,

241,282,337]

[59,120,172,

227,276,323]

[73,142,204,

259,318,363]

[71,136,200,

259,314,369]

[80,152,219,

281,343,398]

DMNC

[61,116,149,

192,249,292]

[61,119,163,

215,274,339]

[61,131,164,

219,274,316]

[69,136,185,

255,308,357]

[61,120,164,

204,275,338]

[72,145,199,

273,330,386]

NC

[78,143,200,

250,290,337]

[84,147,208,

260,309,355]

[81,141,207,

261,310,342]

[86,155,215,

275,320,375]

[80,145,205,

259,308,346]

[84,154,226,

287,339,390]

TP

[55,106,150,

194,236,282]

[64,120,179,

235,280,323]

[59,118,174,

220,268,310]

[70,140,205,

262,314,356]

[72,134,198,

260,322,372]

[79,154,221,

283,341,395]

LID

[82,142,199,

251,303,347]

[82,142,206,

260,316,354]

[83,149,214,

271,317,364]

[86,155,226,

281,337,385]

[82,151,214,

265,316,371]

[85,156,227,

292,353,405]

BC

[48,83,123,

164,207,247]

[51,107,160,

210,253,292]

[52,93,135,

177,215,250]

[62,114,165,

210,259,290]

[54,110,160,

213,262,305]

[67,127,189,

228,280,324]

CC

[49,90,134,

178,225,263]

[57,107,159,

203,256,290]

[53,103,143,

188,230,264]

[65,121,173,

211,266,304]

[67,120,171,

227,282,339]

[70,126,179,

242,304,365]

PR

[51,94,145,

190,246,291]

[61,116,178,

232,277,326]

[55,103,153,

206,255,303]

[67,129,187,

244,295,344]

[60,110,182,

233,283,327]

[70,140,205,

260,315,368]

LR

[58,104,151,

194,234,269]

[65,123,173,

215,255,290]

[60,108,149,

196,230,265]

[66,127,177,

213,254,304]

[69,125,173,

209,244,291]

[78,135,181,

230,277,335]

PeC

[74,141,202,

250,296,331]

[83,160,220,

277,322,359]

[73,138,198,

250,301,335]

[85,159,220,

279,323,364]

[75,149,199,

255,298,339]

[85,164,226,

281,331,369]

WDC

[76,146,218,

268,321,367]

[82,158,227,

282,340,386]

[74,146,208,

262,316,358]

[84,161,223,

289,337,386]

[80,150,213,

284,328,369]

[88,166,236,

303,353,397]