Table 3 Symbolic representation

D

The gene expression matrix

d _i

i^thgene in D

δ

Signum threshold

G

Co-expression network

V

Set of vertices in G

E

Set of edges in G

Dist

Distance matrix

Dist(d _i , d _j )

NMRS distance between genes d _i , d _j ∈D

Adj

Adjacency matrix

Adj(v _i ,v _j )

1 if v _i and v _j are connected by an edge 0 otherwise

G ^con

Set of connected region

i^th connected region

Set of vertices in i^th connected region

Set of edges in i^th connected region

Adjacency matrix of the i^th connected region

i^th network module

D ^net

Set of network modules obtained from G

TOM(v _i ,v _j )

Topological Matrix value between vertices v _i and v _j

TOM(V₁)

Average TOM of the set of vertices V₁

TOM for i^th connected region

Maximum spanning tree obtained from i^th connected region

Set of edges in