Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris

Table 3 Predicted binding affinities of Dsg3 peptide sequences to DQB1*0503.

Rank	Peptide	Sequence	Predicted BE (kJ/mol)	References
1	Dsg3 206–220	TPMFLLSRNTGEVRT	-30.53	Wucherpfennig et al. (1995)
2	Dsg3 189–205	HLNSKIAFKIVSQEPAG	-29.10	Veldman et al. (2004)
3	Dsg3 78–94	QATQKITYRISGVGIDQ	-27.14	Veldman et al. (2004)
4	Dsg3 190–204	LNSKIAFKIVSQEPA	-26.88	Wucherpfennig et al. (1995)
5	Dsg3 251–265	CECNIKVKDVNDNFP	-26.65	Wucherpfennig et al. (1995)
6*	Dsg3 762–786	QSGTMRTRHSTGGTNKDYADGAISM	-22.42	Wucherpfennig et al. (1995)

Predicted binding affinities of Dsg3 peptide sequences to DQB1*0503. '*' indicates non-immunostimulatory in the relevant experiments.

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