Figure 4

Model validation for case II. Model validation using optimal estimates obtained with different computational approaches. Dashed curves represent the predicted profiles using optimal estimates obtained from estimation without accounting for flux connectivity constraints. Solid curves represent the predicted profiles using the optimal estimates obtained from an estimation accounting for noise-free flux connectivity constraints. Dashed-dot-dot curves represent the predicted profiles using the optimal estimates obtained from an estimation accounting for 5% noise in the measured flux connectivity constraints. Data points are in silico observations. The independent variables are set 5% outside the training range.