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  1. Content type: Methodology article

    To ensure cancer patients are stratified towards treatments that are optimally beneficial, it is a priority to define robust molecular subtypes using clustering methods applied to high-dimensional biological d...

    Authors: Katherine Eason, Gift Nyamundanda and Anguraj Sadanandam

    Citation: BMC Bioinformatics 2018 19:182

    Published on:

  2. Content type: Software

    A quantitative trait locus (QTL) is a genomic region that correlates with a phenotype. Most of the experimental information about QTL mapping studies is described in tables of scientific publications. Traditio...

    Authors: Gurnoor Singh, Arnold Kuzniar, Erik M. van Mulligen, Anand Gavai, Christian W. Bachem, Richard G.F. Visser and Richard Finkers

    Citation: BMC Bioinformatics 2018 19:183

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  3. Content type: Research article

    Link prediction in biomedical graphs has several important applications including predicting Drug-Target Interactions (DTI), Protein-Protein Interaction (PPI) prediction and Literature-Based Discovery (LBD). I...

    Authors: Gamal Crichton, Yufan Guo, Sampo Pyysalo and Anna Korhonen

    Citation: BMC Bioinformatics 2018 19:176

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  4. Content type: Software

    Complex microbial communities are an area of growing interest in biology. Metatranscriptomics allows researchers to quantify microbial gene expression in an environmental sample via high-throughput sequencing....

    Authors: Samuel T. Westreich, Michelle L. Treiber, David A. Mills, Ian Korf and Danielle G. Lemay

    Citation: BMC Bioinformatics 2018 19:175

    Published on:

  5. Content type: Methodology article

    There is growing interest in utilizing artificial intelligence, and particularly deep learning, for computer vision in histopathology. While accumulating studies highlight expert-level performance of convoluti...

    Authors: Kevin Faust, Quin Xie, Dominick Han, Kartikay Goyle, Zoya Volynskaya, Ugljesa Djuric and Phedias Diamandis

    Citation: BMC Bioinformatics 2018 19:173

    Published on:

  6. Content type: Methodology

    In phylogenetic reconstruction the result is a tree where all taxa are leaves and internal nodes are hypothetical ancestors. In a live phylogeny, both ancestral and living taxa may coexist, leading to a tree w...

    Authors: Guilherme P. Telles, Graziela S. Araújo, Maria E. M. T. Walter, Marcelo M. Brigido and Nalvo F. Almeida

    Citation: BMC Bioinformatics 2018 19:172

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  7. Content type: Software

    Standard cone-beam computed tomography (CBCT) involves the acquisition of at least 360 projections rotating through 360 degrees. Nevertheless, there are cases in which only a few projections can be taken in a ...

    Authors: Claudia de Molina, Estefania Serrano, Javier Garcia-Blas, Jesus Carretero, Manuel Desco and Monica Abella

    Citation: BMC Bioinformatics 2018 19:171

    Published on:

  8. Content type: Correction

    After publication of the original article [1], it has been found that the author affiliations have been accidentally left out in the PDF. The full affiliations can be found in this correction:

    Authors: Taehoon Lee, Sungmin Lee, Woo Young Sim, Yu Mi Jung, Sunmi Han, Joong-Ho Won, Hyeyoung Min and Sungroh Yoon

    Citation: BMC Bioinformatics 2018 19:170

    Published on:

    The original article was published in BMC Bioinformatics 2018 19:44

  9. Content type: Methodology article

    Zebrafish is a widely used model organism for studying heart development and cardiac-related pathogenesis. With the ability of surviving without a functional circulation at larval stages, strong genetic simila...

    Authors: Chia-Pin Kang, Hung-Chi Tu, Tzu-Fun Fu, Jhe-Ming Wu, Po-Hsun Chu and Darby Tien-Hao Chang

    Citation: BMC Bioinformatics 2018 19:169

    Published on:

  10. Content type: Research

    Comprehensively understanding the dynamics of biological systems is among the biggest current challenges in biology and medicine. To acquire this understanding, researchers have measured the time-series expres...

    Authors: Yoichi Takenaka, Kazuma Mikami, Shigeto Seno and Hideo Matsuda

    Citation: BMC Bioinformatics 2018 19(Suppl 4):89

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  11. Content type: Research

    Protein dihedral angles provide a detailed description of protein local conformation. Predicted dihedral angles can be used to narrow down the conformational space of the whole polypeptide chain significantly,...

    Authors: Yujuan Gao, Sheng Wang, Minghua Deng and Jinbo Xu

    Citation: BMC Bioinformatics 2018 19(Suppl 4):100

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  12. Content type: Research

    As one possible solution to the “missing heritability” problem, many methods have been proposed that apply pathway-based analyses, using rare variants that are detected by next generation sequencing technology...

    Authors: Sungyoung Lee, Yongkang Kim, Sungkyoung Choi, Heungsun Hwang and Taesung Park

    Citation: BMC Bioinformatics 2018 19(Suppl 4):79

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  13. Content type: Research

    Even though coexistence of multiple phenotypes sharing the same genomic background is interesting, it remains incompletely understood. Epigenomic profiles may represent key factors, with unknown contributions ...

    Authors: Y.-H. Taguchi

    Citation: BMC Bioinformatics 2018 19(Suppl 4):99

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  14. Content type: Research

    The genomic similarity is a large-scale measure for comparing two given genomes. In this work we study the (NP-hard) problem of computing the genomic similarity under the DCJ model in a setting that does not a...

    Authors: Diego P. Rubert, Edna A. Hoshino, Marília D. V. Braga, Jens Stoye and Fábio V. Martinez

    Citation: BMC Bioinformatics 2018 19(Suppl 6):152

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 6

  15. Content type: Research

    Frequent subgraphs mining is a significant problem in many practical domains. The solution of this kind of problem can particularly used in some large-scale drug molecular or biological libraries to help us fi...

    Authors: Shunyun Yang, Runxin Guo, Rui Liu, Xiangke Liao, Quan Zou, Benyun Shi and Shaoliang Peng

    Citation: BMC Bioinformatics 2018 19(Suppl 4):98

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  16. Content type: Research

    Synthetic virology is an important multidisciplinary scientific field, with emerging applications in biotechnology and medicine, aiming at developing methods to generate and engineer synthetic viruses. In part...

    Authors: Eli Goz, Yael Tsalenchuck, Rony Oren Benaroya, Zohar Zafrir, Shimshi Atar, Tahel Altman, Justin Julander and Tamir Tuller

    Citation: BMC Bioinformatics 2018 19(Suppl 6):140

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 6

  17. Content type: Database

    Protein-protein interactions (PPIs) play several roles in living cells, and computational PPI prediction is a major focus of many researchers. The three-dimensional (3D) structure and binding surface are impor...

    Authors: Takanori Hayashi, Yuri Matsuzaki, Keisuke Yanagisawa, Masahito Ohue and Yutaka Akiyama

    Citation: BMC Bioinformatics 2018 19(Suppl 4):62

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  18. Content type: Research

    Protein secondary structure is the three dimensional form of local segments of proteins and its prediction is an important problem in protein tertiary structure prediction. Developing computational approaches ...

    Authors: Jiyun Zhou, Hongpeng Wang, Zhishan Zhao, Ruifeng Xu and Qin Lu

    Citation: BMC Bioinformatics 2018 19(Suppl 4):60

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  19. Content type: Research

    A new emerged cancer treatment utilizes intrinsic immune surveillance mechanism that is silenced by those malicious cells. Hence, studies of tumor infiltrating lymphocyte populations (TILs) are key to the succ...

    Authors: Shu-Hwa Chen, Wen-Yu Kuo, Sheng-Yao Su, Wei-Chun Chung, Jen-Ming Ho, Henry Horng-Shing Lu and Chung-Yen Lin

    Citation: BMC Bioinformatics 2018 19(Suppl 4):154

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

  20. Content type: Research

    Although rapid developed sequencing technologies make it possible for genotype data to be used in clinical diagnosis, it is still challenging for clinicians to understand the results of sequencing and make cor...

    Authors: Xiaofeng Gong, Jianping Jiang, Zhongqu Duan and Hui Lu

    Citation: BMC Bioinformatics 2018 19(Suppl 4):162

    Published on:

    This article is part of a Supplement: Volume 19 Supplement 4

Page 1 of 352

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