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Table 5 Statistics of the benchmark datasets: homogeneous dataset, strictly one EC number per family

From: Combining specificity determining and conserved residues improves functional site prediction

Family ID Family name # sequences Alignment length EC PDB Bound ligand equivalent to natural substrate/product
PF00303 Thymidylat_
synt
19 384 2.1.1.45 2G8O 2'-deoxyuridine 5'-monophosphate, 10-propargyl-5,8-dideazafolic acid
PF00693 Herpes_TK 15 305 2.7.1.21 1VTK Adenosine-5'-diphosphate, thymidine-5'-phosphate
PF00925 GTP_
cyclohydro2
16 193 3.5.4.25 2BZ0 Phosphomethylphosphonic acid guanylate ester
PF01014 Uricase 17 196 1.7.3.3 2FXL 1-(2,5-dioxo-2,5-dihydro-1h-imidazol-4-yl)urea
PF01227 GTP_
cyclohydroI
16 107 3.5.4.16 1A8R Guanosine-5'-triphosphate
PF01293 PEPCK_ATP 12 495 4.1.1.49 1YTM Adenosine-5'-triphosphate, oxalic acid
PF01583 APS_kinase 20 166 2.7.1.25 1M7G Adenosine-5'-phosphosulfate, adenosine-5'-diphosphate-2',3'-vanadate
PF01656 CbiA 80 372 6.3.3.3 1A82 Adenosine-5'-triphosphate, 7,8-diamino-nonanoic acid
PF01702 TGT 13 256 2.4.2.29 1Q2S 9-deazaguanine
PF01747 ATP-
sulfurylase
19 397 2.7.7.4 1G8H Adenosine-5'-phosphosulfate, pyrophosphate 2-
PF02110 HK 9 282 2.7.1.50 1ESQ Adenosine-5'-triphosphate, 4-methyl-5-hydroxyethylthiazole phosphate
PF02223 Thymidylate_
kin
26 209 2.7.4.9 1E9E Adenosine-5'-diphosphate, thymidine-5'-phosphate
PF02277 DBI_PRT 28 398 2.4.2.21 1L5L 7-alpha-d-ribofuranosyl-purine-5'-phosphate, nicotinic acid
PF02353 CMAS 12 304 2.1.1.79 1KPI S-adenosyl-Ll-homocysteine
PF02569 Pantoate_
ligase
7 311 6.3.2.1 2A86 Adenosine monophosphate, beta-alanine
PF02898 NO_synthase 8 374 1.14.13.39 1Q2O L-n(omega)-nitroarginine-2,4-L-diaminobutyric amide
PF02901 PFL 11 734 2.3.1.54 1MZO Pyruvic acid
PF03332 PMM 9 248 5.4.2.8 2FUE Alpha-d-mannose 1-phosphate