Figure 5From: Modeling the role of p53 pulses in DNA damage- induced cell death decisionDynamics of the integrated model. Upper panel: Time course plot of oligomerized Bax (violet). Lower panel: Time course plot of p53 (blue) and PUMA (green). PUMA levels are gradually accumulated, ratcheting up at each p53 pulse until it reaches a threshold level at which the Bax activation switch turns on (IR = 0.3, 3, and 20 Gy respectively).Back to article page