Figure 5
From: ResBoost: characterizing and predicting catalytic residues in enzymes
Comparison of ResBoost, ConSurf score thresholding, ET score thresholding, and global conservation methods on Magnaporthe grisea scytalone dehydratase (PDB ID: 1std). For a fixed specificity, ResBoost is more sensitive than ConSurf, ET, and global conservation. The tradeoff parameter k for ResBoost is set to 128. ResBoost predicts all residues listed as catalytic in the Catalytic Site Atlas (CSA) i.e., Tyr30, Asp31, Tyr50, His85, and His110. ConSurf correctly predicts four catalytic residues (Asp31, Tyr50, His85, and His110), ET predicts three (Asp31, His85, and His 110) while global conservation predicts none. ResBoost alone predicts Ser129 and Asn131 – residues which are known to be catalytic based on experimental evidence but are not listed in the CSA [26].