Figure 1

A-MADMAN architecture. A-MADMAN includes console, job server and web-application. The console allows data retrieval, import and database filling. The web application is the user friendly and collaborative core of the system allowing data inspection, annotation and analysis. A Project is a collection of samples, series, tags, baskets and analyses owned by a user or by a group of users. Series and samples data and metadata come from GEO. The user can create an annotation system based on tags and assign samples to individuals. Queries on Boolean combinations of annotation tags are used to select and extract groups of samples, giving rise to baskets. One or more baskets are passed to a customisable analysis workflow (a job server is in charge for asynchronous execution of jobs) outputting an R workspace, facilitating following analyses.