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Table 2 Percentages of significant cases detected (Detected) and false discovery rate (FDR) after multitest adjustment when the p-values come from families of one-sample t tests where some (% effect) of the alternative hypotheses were true.

From: A new multitest correction (SGoF) that increases its statistical power when increasing the number of tests

  Weak    SB BH SGoF
N % effect S Significant Detected FDR Detected FDR Detected FDR
5 5% 100 5.2 0.04 98 0.04 98 0.07 85
5 5% 1000 5.2 0.01 78 0.01 80 0.01 91
5 5% 10000 5.2 0.00 91 0.00 88 0.02 89
5 10% 100 5.4 0.06 86 0.06 87 0.09 83
5 10% 1000 5.5 0.01 83 0.01 84 0.04 78
5 10% 10000 5.5 0.00 80 0.00 83 0.11 80
5 20% 100 5.9 0.08 57 0.08 60 0.12 64
5 20% 1000 6.0 0.01 57 0.01 58 0.13 63
5 20% 10000 6.0 0.00 70 0.00 69 0.54 63
    Mean 0.02 77.8 0.02 78.6 0.12 77.3
    SD 0.030 14.18 0.030 13.45 0.161 11.24
10 5% 100 5.7 0.05 72 0.06 70 0.09 80
10 5% 1000 5.6 0.01 69 0.01 67 0.06 77
10 5% 10000 5.6 0.00 71 0.00 71 0.22 74
10 10% 100 6.2 0.06 56 0.08 57 0.19 67
10 10% 1000 6.2 0.01 44 0.01 47 0.24 59
10 10% 10000 6.3 0.00 44 0.00 45 0.84 61
10 20% 100 7.6 0.12 35 0.15 35 0.52 42
10 20% 1000 7.5 0.01 30 0.02 30 1.14 42
10 20% 10000 7.5 0.00 27 0.00 30 2.11 44
    Mean 0.03 49.8 0.04 50.2 0.60 60.7
    SD 0.041 17.85 0.051 16.72 0.674 15.15
20 5% 100 6.4 0.14 33 0.17 35 0.20 60
20 5% 1000 6.5 0.02 31 0.03 30 0.33 51
20 5% 10000 6.4 0.00 18 0.00 19 1.01 53
20 10% 100 7.8 0.24 17 0.32 18 0.61 38
20 10% 1000 7.9 0.03 13 0.06 16 1.53 36
20 10% 10000 7.9 0.01 7 0.01 10 2.46 40
20 20% 100 10.7 0.36 8 0.57 10 2.24 24
20 20% 1000 10.8 0.06 6 0.15 9 4.38 25
20 20% 10000 10.8 0.01 4 0.04 6 5.35 27
    Mean 0.10 15.22 0.15 17 2.01 39.3
    SD 0.126 10.67 0.188 9.89 1.81 13.02
  1. Weak: The alternative hypothesis is weak implying that data come from a Normal(0.36, 1). N: sample size. % effect: % of real true alternatives. S: number of tests. Significant: % of significants before adjustment. Detected: % of significant tests after adjustment. FDR: false discovery rate. SB: Sequential Bonferroni. BH: Benjamini and Hochberg. SGoF: Sequential Goodness of Fit.
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BMC Bioinformatics

ISSN: 1471-2105

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