Improving detection of differentially expressed gene sets by applying cluster enrichment analysis to Gene Ontology

Table 2 Top significant GO groups identified between AML and ALL for the ALL/AML dataset.

No	GO ID	Term	Rank^a	p-value
1	GO:0042033	chemokine biosynthetic process	-	9e-09
	GO:0045079	negative regulation of chemokine biosynt...	-
	GO:0045080	positive regulation of chemokine biosynt...	-
	GO:0050754	positive regulation of fractalkine biosy...	-
2	GO:0050927	positive regulation of positive chemotax...	-	3.4e-06
	GO:0050930	induction of positive chemotaxis	-
3	GO:0032720	negative regulation of tumor necrosis fa...	-	0.0014
	GO:0032760	positive regulation of tumor necrosis fa...	-
	GO:0042535	positive regulation of tumor necrosis fa...	-
	GO:0042536	negative regulation of tumor necrosis fa...	-
4	GO:0045807	positive regulation of endocytosis	-	0.0058
	GO:0048260	positive regulation of receptor-mediated...	-
	GO:0050766	positive regulation of phagocytosis	-

^a Refers to the rank on the list of the top GO terms enriched by individual GO term analysis for FDR controlled at 5%. The dash (-) indicates that the GO term was not found on the list generated by individual GO term analysis.

ISSN: 1471-2105