Figure 1

Wired phylogenetic trees of V_set and C2_set domains (definitions from Pfam database [21]), respectively zoomed on nodes 41 and 43 (yellow areas). All protein sequences are from the Ensembl database [22]. The multiple alignment was built and annotated using the MACSIMS program [23] and the phylogeny was produced and visualized using the Figenix platform [4]. [Number] represents the identifier of the closest node. Number1_Number2_Number3 represents bootstrap values for the closest internal node (from three construction algorithms [4]). Red circles on nodes represent duplication events. Purple circles represent the detected homolog domains shuffling events. Labeled trees for V_set and C2_set domains are provided [see Additional file 2], [see Additional file 3].