Wired phylogenetic trees of V_set and C2_set domains (definitions from Pfam database ), respectively zoomed on nodes 41 and 43 (yellow areas). All protein sequences are from the Ensembl database . The multiple alignment was built and annotated using the MACSIMS program  and the phylogeny was produced and visualized using the Figenix platform . [Number] represents the identifier of the closest node. Number1_Number2_Number3 represents bootstrap values for the closest internal node (from three construction algorithms ). Red circles on nodes represent duplication events. Purple circles represent the detected homolog domains shuffling events. Labeled trees for V_set and C2_set domains are provided [see Additional file 2], [see Additional file 3].