The case study pathway simulated in CellDesigner. In the legend of the Figure, only part of the participated species is shown, due to its enormous number. x-axis corresponds to time (unit secs here) whereas y-axis corresponds to species concentrations (mol/L). The number of species of the resulted model is 266, including the neighbouring pathways represented as distinct species. For example: the purine, methane, pyrimidine and histidine metabolisms which are shown at the top of the legend. These neighbouring pathways, among others which are not apparent in the legend, take part in the simulation of our resulted model, and offer additional information for the direction of the metabolic flow of the integrated reaction network.