Clustering of protein domains for functional and evolutionary studies

BMC Bioinformatics

Table 1 Nucleotidyl cyclases: residues with best evolutionary split scores.

	Residue number in multiple alignment		Substrate
Evolutionary split score	This paper	Hannenhalli and Russell, 2000	ATP	GTP
113	1509	-	C	V
110	1636	1020	W	F
110	1634	1018	D	C
109	1630	1014	K	M
91	1517	919	I	Y
86	1580	-	F	M
84	1533	935	E	Y
83	1440	-	M	E
83	1497	-	C	Y
81	1656	-	H	Q

The ten residues with the best evolutionary split scores in the multiple sequence alignment of the nucleotidyl cyclases. When the residue had been detected in previous work [10] the corresponding residue number is given. The dominant amino acid for the two subtypes is shown.

ISSN: 1471-2105