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Table 1 Nucleotidyl cyclases: residues with best evolutionary split scores.

From: Clustering of protein domains for functional and evolutionary studies

  Residue number in multiple alignment Substrate
Evolutionary split score This paper Hannenhalli
and Russell,
2000
ATP GTP
113 1509 - C V
110 1636 1020 W F
110 1634 1018 D C
109 1630 1014 K M
91 1517 919 I Y
86 1580 - F M
84 1533 935 E Y
83 1440 - M E
83 1497 - C Y
81 1656 - H Q
  1. The ten residues with the best evolutionary split scores in the multiple sequence alignment of the nucleotidyl cyclases. When the residue had been detected in previous work [10] the corresponding residue number is given. The dominant amino acid for the two subtypes is shown.