Table 1 Inference results for (A) the simple model and (B) autoregulatory model of single gene expression
From: Bayesian inference of biochemical kinetic parameters using the linear noise approximation
(A) Param. | Prior | Value | Estimate 1 | Estimate 2 |
|---|---|---|---|---|
γ R | Γ (0.44,10-2) | 0.44 | 0.43 (0.27-0.60) | 0.49 (0.38-0.61) |
γ P | Γ (0.52,10-2) | 0.52 | 0.51 (0.35-0.67) | 0.49 (0.38-0.61) |
k P | Exp(100) | 10.00 | 21.09 (3.91-67.17) | 11.41 (7.64-16.00) |
λ | Exp(100) | 1.00 | 1.42 (0.60-2.57) | 1.08 (0.76-1.36) |
b 0 | Exp(100) | 15.00 | 6.80 (0.97-18.43) | 12.78 (9.80-15.33) |
b 1 | Exp(1) | 0.40 | 0.79 (0.05-3.02) | 0.29 (0.18-0.43) |
b 2 | Exp(1) | 0.40 | 0.77 (0.08-2.79) | 0.77 (0.32-1.59) |
b 3 | Exp(10) | 7.00 | 6.13 (4.41-7.85) | 7.25 (6.79-7.55) |
b 4 | Exp(100) | 3.00 | 0.94 (0.11-2.88) | 2.87 (2.11-3.52) |
(B) Param. | Prior | Value | Estimate 1 | Estimate 2 |
γ R | Γ (0.44,10-2) | 0.44 | 0.44 (0.27-0.60) | 0.42 (0.32-0.54) |
γ P | Γ (0.52,10-2) | 0.52 | 0.49 (0.33-0.65) | 0.49 (0.36-0.61) |
k P | Exp(100) | 10.00 | 14.86 (3.18-47.97) | 9.35 (5.87-13.15) |
λ | Exp(100) | 1.00 | 1.26 (0.48-2.30) | 1.15 (0.81-1.50) |
b 0 | Exp(100) | 15.00 | 5.99 (0.20-23.06) | 13.47 (9.24-17.13) |
b 1 | Exp(1) | 0.40 | 0.59 (0.01-2.75) | 0.27 (0.14-0.53) |
b 2 | Exp(1) | 0.40 | 0.92 (0.05-2.92) | 0.83 (0.21-3.52) |
b 3 | Exp(10) | 7.00 | 6.53(0.74-14.69) | 7.27 (6.44-7.79) |
b 4 | Exp(100) | 3.00 | 2.85 (0.35-7.19) | 2.64 (1.82-3.32) |