Figure 5

p53 and NF-κB with RB_HUMAN and E2F1_HUMAN. (A) Members of p53 (red circles) and NF-κB (yellow diamonds) networks, their connections with RB_HUMAN (green square) and E2F1_HUMAN (blue square}) cell cycle proteins, and the common components shared between them. Components connecting RB_HUMAN with p53 and NF-κB networks are denoted in green, whilst the components connecting E2F1_HUMAN with the two networks are denoted in blue. (B) A condensed view of only the p53 and NF-κB networks, and their interactions with RB_HUMAN and E2F1_HUMAN proteins. Triangular connector nodes represent common components between RB_HUMAN and the two networks (in green), E2F1_HUMAN and the two networks (in blue), and RB_HUMAN and E2F1_HUMAN connections with the NF-κB and p53 networks (in yellow). Circular nodes in green denote RB_HUMAN connectors to p53 or NF-κB networks; and in blue for E2F1_HUMAN to p53 or NF-κB networks. The yellow and magenta circular nodes represent proteins connecting both E2F1_HUMAN and RB_HUMAN to members of the NF-κB (in yellow) and p53 (in magenta). Refer also to Tables 9, 10, 11, 12 and 13 for further information.