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Figure 1 | BMC Bioinformatics

Figure 1

From: Identifying quantitative operation principles in metabolic pathways: a systematic method for searching feasible enzyme activity patterns leading to cellular adaptive responses

Figure 1

Optimization algorithm based on outer approximation. The original nonconvex problem (upper bound) is depicted in red, whereas the convexified problems (lower bound) are shown in blue color. The master problem is used to provide lower bounds to the global optimum and to initialize the slave problem. The bounds tend to converge as iterations proceed.

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BMC Bioinformatics

ISSN: 1471-2105

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