Figure 3
From: Considering scores between unrelated proteins in the search database improves profile comparison
Effect of the mixing ratio of query- and subject-based distributions. The performance for the distributions produced by unweighted mixture of query- and subject-based scores (red curve) is compared to the schemes that introduce additional weighting, so that the samples of query and subject calibration scores have similar sizes. Increasing the weight of query calibration scores two-fold (blue) or four-fold (green) leads to a monotonic decrease of detection quality. Black, ROC curve for the query calibration alone.