Figure 1

Overview of the analysis process. The proposed method relies on a manually curated database of leukemia-related published gene signatures annotated with terms from a predefined taxonomy. A new microarray dataset is analyzed in two steps. First, each signature is assessed by the global test method to constitute a ranking among the signatures. Secondly, the results from the first step are used to assess terms from the leukemia taxonomy that represent leukemia-related genetic aberrations and molecular mutations.