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Table 2 Ranking of gene signatures.

From: Quantitative comparison of microarray experiments with published leukemia related gene expression signatures

Rank

Gene signature

Taxonomy terms

1

Verhaak et al., Haematologica, 2009, AML, NPM1

NPM1 mutated

2

Verhaak et al., Haematologica, 2009, AML, NPM1 and FLT3-ITD

-

3

Verhaak et al., Haematologica, 2009, AML, NPM1 without FLT3-ITD

NPM1 mutated

4

Verhaak et al., Haematologica, 2009, AML, FLT3-ITD or FLT3-TKD

FLT3

5

Alcalay et al., Blood, 2005, AML, NPM1

NPM1 mutated

6

Verhaak et al., Haematologica, 2009, AML, FLT3-ITD

FLT3-ITD, FLT3

7

Alcalay et al., Blood, 2005, AML, NPM1,

NPM1 mutated

8

Valk et al., N Engl J Med, 2004, Classification of AML subtypes

-

9

Ross et al., Blood, 2004, AML and ALL, t(11q23)/MLL

t(11q23)/MLL, Chrom. aberration

10

Mullighan et al., Leukemia, 2007, AML, NPM1

NPM1 mutated

11

Mullighan et al., Leukemia, 2007, AML, NPM1

NPM1 mutated

12

Verhaak et al., Haematologica, 2009, AML, del(7q)

del(7q)

13

Mullighan et al., Leukemia, 2007, AML, NPM1

NPM1 mutated

14

Verhaak et al., Haematologica, 2009, AML, t(15;17)

t(15;17), Chrom. aberration

15

Marcucci et al., J Clin Oncol, 2008, AML, CEBPA

CEBPA

16

Stirewalt et al., Genes Chromosomes Cancer, 2008, AML

AML, Leukemia

17

Valk et al., N Engl J Med, 2004, AML, CEBPA

CEBPA

18

Ross et al., Blood, 2003, B-ALL, t(11q23)/MLL

-

19

van Delft et al., Br J Haematol, 2005, AML, t(11q23)/MLL

t(11q23)/MLL, Chrom. aberration

20

Valk et al., N Engl J Med, 2004, AML, cluster without predominant characteristics

-

21

Verhaak et al., Blood, 2005, AML, NPM1

NPM1 mutated

22

Langer et al., Blood, 2008, AML, BAALC

-

23

van Delft et al., Br J Haematol, 2005, AML, t(11q23)/MLL

t(11q23)/MLL, Chrom. aberration

24

Armstrong et al., Nat Genet, 2002, ALL, t(11q23)/MLL

t(11q23)/MLL, Chrom. aberration

25

Valk et al., N Engl J Med, 2004, AML, mostly EVI1

-

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  1. Each of the 138 gene signatures was tested for differential expression between NPM1-mutated and NPM1 wild type cases in the query dataset and ranked according to its p-value. All 8 of the 138 signatures associated with the taxonomy term "NPM1 mutated" ranked among the first 21 positions. The complete ranking of all signatures is available in the supplement [Additional file 1: Supplemental Table S4].