Comparison of phylogenetic trees through alignment of embedded evolutionary distances

BMC Bioinformatics

Table 1 AUCs of tested approaches for detecting protein interactions via coevolution.

Methods	AUC (PR curve)¹	AUC (ROC curve)²	p-value³
rCEED ⁴	0.069	0.763 ± 0.013	N/A
rCEED ⁵	0.083	0.766 ± 0.012	0.7965
vCEED	0.091	0.763 ± 0.013	0.9919
mirrortree	0.048	0.687 ± 0.013	<0.0001
tol-mirrortree	0.063	0.722 ± 0.014	<0.0001
phylogenetic vector projection	0.053	0.704 ± 0.013	<0.0001
partial correlation	0.050	0.687 ± 0.013	<0.0001
Interactions identified in DIP⁶	388

¹Area under precision-recall curve
²Area under receiver operating characteristic curve
³The significance was computed using rCEED (observed distances) as reference according to [24].
⁴Based on observed distances
⁵Based on patristic distances after the reconstruction of neighbor joining trees
⁶August 2009 version of DIP.

ISSN: 1471-2105