Table 2 Main function groups of oncogene domains.
From: Analyses of domains and domain fusions in human proto-oncogenes
Go annotation | Domain |
|---|---|
ATP binding | Pkinase, DEAD, Helicase_C, Pkinase_C, MutS_V, MutS_IV, MutS_III MutS_II MutS_I Furin-like, Ephrin_lbd |
protein binding | zf-C3HC4, Death, LRR_1, PDZ, SAMP, EB1_binding, APC_basic, APC_15aa |
DNA/RNA binding | Myb_DNA-binding, P53, bZIP_Maf, bZIP_2, RRM_1, zf-C2H2, zf-C4, bZIP_1, Ets, SAM_PNT |
signal transduction | Cbl_N, wnt, C1_1, Death, RhoGAP, Ras |
growth factor receptor activity | FGF, PDGF, PDGF_N, IGFBP |
protein tyrosine kinase activity | Pkinase, Pkinase_Tyr, SH2, SH3, ig, I-sev, V-set |
regulation of transcription | HLH, RHD, Wos2, Hormone_recep, zf-C4, bZIP_1, Ets, IRF, p53, Myc_N, WT1, E2F_TDP, Myc-LZ, bZIP_Maf, bZIP_2 |
regulation of apoptosis | BH, BH4 |
receptor factor activity/binding | Recep_L_domain, NCD3G, 7tm_1, 7tm_3, PSI |
Wnt receptor signalling pathway | Wnt |
zinc ion binding | zf-C2H2, zf-C3HC4, zf-C4, zf-RanBP |
calcium ion binding | Cadherin, Cadherin_C |
transcription factor activity | Hormone_recep, zf-C4, bZIP_1, Ets, RHD, IRF, P53, Myc_N, E2F_TDP, Myc-LZ |