Table 6 Frequent domain pairs XY in the oncogene graph compared with the background genome.
From: Analyses of domains and domain fusions in human proto-oncogenes
Number | Domain X | Domain Y | n s | m s | Enrichment ratio | p-value |
|---|---|---|---|---|---|---|
1 | SH2 | SH3 | 63 | 16 | 51.25 | 6.84E-19 |
2 | SH2 | Pkinase_Tyr | 41 | 11 | 54.15 | 7.83E-17 |
3 | SH3 | Pkinase_Tyr | 32 | 9 | 56.76 | 3.42E-14 |
4 | SAM_PNT | Ets | 13 | 5 | 77.62 | 3.43E-09 |
5 | Furin-like | Pkinase_Tyr | 8 | 4 | 100.91 | 3.96E-08 |
6 | Recep_L_domain | Pkinase_Tyr | 8 | 4 | 100.91 | 3.96E-08 |
7 | Furin-like | Recep_L_domain | 10 | 4 | 80.73 | 1.18E-07 |
8 | Jun | bZIP_1 | 3 | 3 | 201.81 | 1.19E-07 |
9 | Pkinase | RBD | 4 | 3 | 151.36 | 4.73E-07 |
10 | C1_1 | RBD | 5 | 3 | 121.09 | 1.18E-06 |
11 | Myc_N | HLH | 5 | 3 | 121.09 | 1.18E-06 |
13 | ig | Pkinase_Tyr | 27 | 4 | 29.9 | 9.23E-06 |